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        楊崇林

        發布時間:2018年03月27日        點擊量:

         

        楊崇林,男,1967年生,云南大學生命科學學院院長,云南大學生命科學研究中心主任,博士,博士生    導師。

        教育與研究經歷:

        1998年于北京大學獲博士學位。

        1998-1999年為意大利International school for advanced studies分子神經生物學實驗室訪問學者。

        1999-2005年先后在University of Maryland School of Medicine和University of Colorado從事博士后研究。

        2006年入選中國科學院 "百人計劃",終期獲評優秀。

        2010年獲國家杰出青年基金資助。2013年被中國科協授予“全國優秀科技工作者”榮譽稱號。2017年入選“國家百千萬人才工程”。

        楊崇林教授長期以來致力于探索以溶酶體為中心的重要細胞生物學問題,在溶酶體介導的凋亡細胞降解、內吞體-溶酶體運輸、溶酶體發生的調控機制等領域取得突破性進展。他首次揭示了在進化上保守的凋亡細胞吞噬受體CED-1的偱環機制及其介導的細胞骨架重排的信號傳導機制。楊崇林教授發現了多個在進化上保守的調控內吞體-溶酶體運輸的新基因,并系統地揭示了它們在早-晚期內吞體轉換及溶酶體運輸中的作用機制。運用化學生物學研究方法,他發現了溶酶體發生的新的信號傳導和調控機制,為以促進溶酶體發生為基礎的神經退行性疾病的治療提供了重要理論依據。這些出色的研究成果分別發表在包括Science, Nature Cell Biology, Journal of Cell Biology, Cell Research, PLoS Genetics等在內的重要國際學術期刊上,在國際學術界引起了廣泛的反響。

           

        近年來發表的主要代表性論著包括:

        1.      Kai Liu, Ruxiao Xing, Youli Jian, Zhiyang Gao, Xinli Ma, Xiaojuan Sun, Yang Li, Meng Xu, Xin Wang, Yudong Jing, Weixiang Guo and Chonglin Yang. (2017). WDR91 is a Rab7 effector required for neuronal development. The Journal of Cell Biology. 216(10): 3307-3321.

        2.      Jianhua Yin, Yaling Huang, Pengfei Guo, Siqi Hu, Sawako Yoshina, Nan Xuan, Qiwen Gan, Shohei Mitani, Chonglin Yang, Xiaochen Wang. (2017). GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. The Journal of Cell Biology. (Online, DOI: 10.1083/jcb.201610001)

        3.      Chonglin Yang, Xiaochen Wang. (2017). Cell Biology in China: Focusing on the Lysosome. Traffic, DOI: 10.1111/tra.12483 | Published Mar 30, 2017.

        4.      Xuezhao Liu, Yang Li, Xin Wang, Ruxiao Xing, Kai Liu, Qiwen Gan, Changyong Tang, Zhiyang Gao, Youli Jian, Shouqing Luo, Weixiang Guo, and Chonglin Yang. (2017). The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy, The Journal of Cell Biology, DOI: 10.1083/jcb.201608039 | Published April 12, 2017.

        5.      Shiya Cheng, Kai Liu, Chonglin Yang, Xiaochen Wang. (2017). Dissecting Phagocytic Removal of Apoptotic Cells in Caenorhabditis elegans. Methods in Molecular Biology: Phagocytosis and Phagosomes (Eds. Roberto Botelho ), Springer New York, 1519: 265-284. Print ISBN: 978-1-4939-6579-3.

        6.      Yuan Li, Baohui Chen, Wei Zou, Xin Wang, Yanwei Wu, Dongfeng Zhao, Yanan Sun, Yubing Liu, Lianwan 5. Chen, Long Miao, Chonglin Yang, Xiaochen Wang. (2016). The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. The Journal of Cell Biology 215(2), 167-185.

        7.      Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, XinWang,Youli Jian, Guihua Tang, Changyong Tang, Yingtong Di, Shuzhen Mu, Xuezhao Liu, Kai Liu, Ting Li,Yingchun Wang, Long Miao, Weixiang Guo, Xiaojiang Hao and Chonglin Yang. (2016). Protein kinase C controls lysosome biogenesis independently of mTORC1. Nature Cell Biology 18, 1065-1077.

        8.      Xiaochen Wang, Chonglin Yang. (2016). Programmed cell death and clearance of cell corpses in Caenorhabditis elegans. Cellular and Molecular Life Sciences 73, 2221-2236.

        9.      Kai Liu, Youli Jian, Xiaojuan Sun,Chengkui Yang,Zhiyang Gao, Zhili Zhang, Xuezhao Liu,Yang Li,Jing Xu,Yudong Jing,Shohei Mitani,Sudan He, Chonglin Yang. (2016). Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. The Journal of Cell Biology 212(2), 181-198.

        10. Meng Xu, Yubing Liu, Liyuan Zhao, Qiwen Gan, Xiaochen Wang, and Chonglin Yang. (2014). The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Molecular Biology of the Cell 25, 2071-2083.

        11. Didi Chen, Youli Jian, Xuezhao Liu, Yuanya Zhang, Jingjing Liang, Xiaying Qi, Hongwei Du, Wei Zou, Lianwan Chen, Yongping Chai, Guangshuo Ou, Long Miao, Yingchun Wang, and Chonglin Yang. (2013). Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genetics 9(5), e1003517.

        12. Jing Xu, Xiaojuan Sun, Yudong Jing, Mo Wang, Kai Liu, Youli Jian, Mei Yang, Zhukuan Cheng, Chonglin Yang. (2012). MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells. Cell Research 22, 886-902.

        13. Didi Chen, Hui Xiao, Kai Zhang, Bin Wang,Zhiyang Gao, Youli Jian, Xiaying Qi, Jianwei Sun, Long Miao, Chonglin Yang. (2010). Retromer Is Required for Apoptotic Cell Clearance by Phagocytic Receptor Recycling. Science 327, 1261-1264.

        14. Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, and Chonglin Yang. (2009). Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery to Promote Apoptosis in Caenorhabditis elegans. Molecular and Cellular Biology 29, 3881-3893.

        15. Mei Yang, Jianwei Sun, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao, Chonglin Yang. (2009). Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis. PLoS Genetics 5(6), e1000514.

        16. Hui Xiao, Didi Chen, Zhou Fang, Xiaojuan Sun, Jing Xu, Song Song, Jiajia Liu and Chonglin Yang. (2009). Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Molecular Biology of the Cell 20, 21-32.

        17. Youli Jian, Zhiyang Gao, Jianwei Sun, Qinfang Shen, Feng Feng,Yudong Jing and Chonglin Yang. (2009). RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells. Oncogene 28, 4201-4211.

        18. Chonglin Yang, Myoung Sook Kim, Devulapalli Chakravarty, Fred E. Indig and France Carrier. (2009). Nucleolin Binds to the Proliferating Cell Nuclear Antigen and Inhibits Nucleotide Excision Repair. Molecular and Cellular Pharmacology 1, 130-137.

        19. Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichuan Gu, Chun-Ling Sun, Chonglin Yang, Yong Shi, Tetsuo Kobayashi, Yigong Shi,Shohei Mitani, Xiao-Song Xie & Ding Xue (2007). C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nature Cell Biology 9, 541-549.

        20. Chonglin Yang, Nieng Yan, Jay Parish, Xiaochen Wang, Yigong Shi and Ding Xue. (2006). RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in C. elegans. Journal of Biological Chemistry 281, 9137-9144.

           

        發表專利

                專利名稱:大豆胞囊線蟲RNA解旋酶CGH-1及其編碼基因與應用,專利號:ZL201110317555.5發  明 人:楊崇林,張勁松,陳受宜,李海潮,荊玉棟,蹇友理,李金英,王昉,李錦錦

        專利名稱:巨大戟醇及其衍生物在增強溶酶體生成中的應用,專利申請號:201610183289.4,發明人:楊崇林、郝小江、李洋、丁驍、徐猛、晏晨、邸迎彤、穆淑珍、蹇友理、宋智琴、郭偉翔

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